Paul.xu: Created page with "Molecular adjuvants and immunogenicity of DNA vaccines in animals. {| border="0" cellspacing="0" |- | '''Adjuvants''' | '''Antigens''' | '''Delivery''' | '''Host''' | '''Resp..."

2019-08-28T21:34:39Z

Created page with "Molecular adjuvants and immunogenicity of DNA vaccines in animals. {| border="0" cellspacing="0" |- | '''Adjuvants''' | '''Antigens''' | '''Delivery''' | '''Host''' | '''Resp..."

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Molecular adjuvants and immunogenicity of DNA vaccines in animals.

{| border="0" cellspacing="0"
|-
| '''Adjuvants'''
| '''Antigens'''
| '''Delivery'''
| '''Host'''
| '''Responses'''
|-
| colspan="6" | '''Costimulatory molecules'''
|-
| height="98" | CD80, CD86
| HIV-1 (Env, Gag, Pol)
| DC, IM
| Mouse Chimpanzee
| +CMI
|-
| CD40 LT
| beta-gal
| DC, SC
| Mouse
| +Ab, +CMI
|-
| ICAM-1
| HIV-1 (Env)
| DC, IM
| Mouse
| +CMI
|-
| colspan="6" | '''Cytokines'''
|-
| height="98" | IL-2, IFN-γ
| HIV-1 (Env, Gag, Pol)
| DC, IM
| Mouse
| +Ab, +CMI
|-
| IL-6
| Influenza (HA)
| DC, GG
| Mouse
| +Ab
|-
| IL-2,12, IFN-γ
| HBV
| DC, IM
| Mouse
| +CMI
|-
| height="98" | TNF-α, IL-15
| HIV (Env, Gag, Pol)
| DC, IM
| Mouse
| +CMI
|-
| colspan="6" | '''Toll like receptor adaptor/signaling molecules'''
|-
| height="143" | TRIF
| Influenza (HA), tumor E7
| BC, IM/EP
| Mouse
| +CMI
|-
| height="143" | MyD88
| Influenza (HA), tumor E7
| BC, IM/EP
| Mouse
| +Ab
|-
| height="98" | FliC
| Influenza A (Np)
| DC, ID
| Mouse
| +Ab, +CMI
|-
| height="98" | IRF 1,3, 7
| Influenza virus (HA, Np)
| DC/BC, IM
| Mouse
| +Ab, +CMI
|-
| TBK-1
| P. f (SE36)
| DC, IM
| Mouse
| +Ab, +CMI
|-
| height="98" | HMGB1
| HIV-1 (Gag, Env)
| DC, IM/EP
| Mouse
| +Ab, +CMI
|-
| DAI
| Survivin
| DC, ID
| Mouse
| +CMI
|-
| chMDA5
| Influenza (HA)
| DC, IM
| Chicken
| +Ab
|-
| Ii
| P. f (ME)
| FC, IM
| Mouse
| +CMI
|-
| colspan="6" | '''Toxins/Viral proteins'''
|-
| FrC
| Sc-fv
| FC, IM
| Mouse
| +Ab
|-
| DTa
| HIV (Gag)
| BC, ID
| Mouse
| −CMI
|-
| NSP4
| HCV NS3
| BC, ID
| Mouse
| +/−CMI
|-
| height="98" | VSVG
| HIV (Gag) NS3
| DC, ID BC, ID
| Mouse Mouse
| +CMI +/−CMI
|-
| colspan="6" | '''Heat shock proteins'''
|-
| height="98" | Calreticulin
| mucin 1 HPV-16 E7
| DC FC, GG
| Mouse Mouse
| +CMI +CMI
|-
| HSP70
| HIV (Gag)
| BC, ID
| Mouse
| +CMI
|-
| colspan="6" | '''Complement inhibitor'''
|-
| IMX313
| HIV (Tat)
| FC, ID
| Mouse
| +Ab, +CMI
|-
| colspan="6" | '''Cytolytic protein'''
|-
| height="188" | PRF
| HIV (Gag) HCV (NS3) HCV (NS345B)
| BC, ID BC, ID BC, ID
| Mouse Mouse, Pig Mouse
| +CMI +CMI +CMI
|}

Adjuvants: LT: ligand/trimer, IL: Interleukin, TNF: Tumor necrosis factor, TRIF: Toll-interleukin-1 receptor domain-containing adaptor-inducing beta interferon, MyD88: myeloid differentiation primary response, FliC: phase-1 flagellin, IRF: Interferon regulatory factor, TBK-1: TANK-binding kinase 1, HMGB1: High-mobility group box 1 protein, DAI: DNA-dependent activator of interferon (IFN) regulatory factors, chMDA5: melanoma differentiation-associated gene 5 product, FrC: Fragment C of tetanus toxin, DTa: Diphtheria toxin subunit A, NSP4: Nonstructural protein 4, li: MHC class II invariant chain, HSP: Heat shock protein, VSVG: Vesicular stomatitis virus, PRF: Perforin; Antigens: HIV: Human immunodeficiency virus, Env: Envelope, GAG: Group antigens, Pol: Reverse transcriptase, beta-gal: beta galactosidase, FMDV: Foot and Mouth Disease Virus, VP1: Virus protein 1, HBV: Hepatitis B virus, HA: Haemagglutinin, Sc-fv: Single chain fragment variable, Np: Nucleoprotein, P.f: Plasmodium falciparum, SE36: serine repeat antigen 36, HCV: Hepatitis C virus, NS3: Nonstructural protein 3, ME: Multiepitope string fused to the native P. falciparum T9/96 strain,NS345B: Nonstructural proteins 3, 4, 5B; Delivery: DC: Different constructs, BC: Bicistronic construct, FC: Fusion protein/single construct, IM: Intra muscular, SC: Subcutaneous, GG: Gene gun, EP: Electroporation, ID: Intradermal; Responses: +: Increase, −: Decrease, +/−: No significant change, CMI: T cell responses, Ab: Humoral responses; 

'''Molecular adjuvants tested with DNA vaccines in humans.'''

{| border="0" cellspacing="0"
|-
| '''Adjuvants'''
| '''Antigens'''
| '''Delivery'''
| '''Responses'''
| '''Trial Phase'''
|-
| height="98" | IL-12, IL-15
| HIV-1 (Gag)
| DC, IM
| +/−Ab, +/−CMI
| I
|-
| GM-CSF, IL-2
| Her2
| RP, IM
| +Ab, +CMI
| I
|-
| GM-CSF
| CEA
| RP, ID
| +Ab, +CMI
| I
|-
| height="143" | IL-2/Ig
| HIV-1 Gag/Pol/Nef/Env
| BC, IM
| +Ab, +CMI
| I
|-
| height="143" | IL-12
| HIV (MAG-Gag, Pol, Env, Nef, Tat, Vif)
| DC, IM/EP
| −Ab, +CMI
| I
|-
| height="98" | IL-12
| HIV-1 (Env, Gag, Pol)
| DC, IM/EP
| +CMI
| I
|-
| GM-CSF
| PAP
| RPID
| −Ab, +CMI
| I/IIa
|-
| HSP70
| HPV16 (E7)
| FC, IM
| −Ab, +/−CMI
| I
|-
| height="98" | TNF-α, IL-15
| HIV (Env, Gag, Pol)
| DC, IM
| Mouse
| +CMI
|-
| colspan="6" | '''Toll like receptor adaptor/signaling molecules'''
|-
| height="143" | TRIF
| Influenza (HA), tumor E7
| BC, IM/EP
| Mouse
| +CMI
|-
| height="143" | MyD88
| Influenza (HA), tumor E7
| BC, IM/EP
| Mouse
| +Ab
|-
| height="98" | FliC
| Influenza A (Np)
| DC, ID
| Mouse
| +Ab, +CMI
|-
| height="98" | IRF 1,3, 7
| Influenza virus (HA, Np)
| DC/BC, IM
| Mouse
| +Ab, +CMI
|-
| TBK-1
| P. f (SE36)
| DC, IM
| Mouse
| +Ab, +CMI
|-
| height="98" | HMGB1
| HIV-1 (Gag, Env)
| DC, IM/EP
| Mouse
| +Ab, +CMI
|-
| DAI
| Survivin
| DC, ID
| Mouse
| +CMI
|-
| chMDA5
| Influenza (HA)
| DC, IM
| Chicken
| +Ab
|-
| Ii
| P. f (ME)
| FC, IM
| Mouse
| +CMI
|-
| colspan="6" | '''Toxins/Viral proteins'''
|-
| FrC
| Sc-fv
| FC, IM
| Mouse
| +Ab
|-
| DTa
| HIV (Gag)
| BC, ID
| Mouse
| −CMI
|-
| NSP4
| HCV NS3
| BC, ID
| Mouse
| +/−CMI
|-
| height="98" | VSVG
| HIV (Gag) NS3
| DC, ID BC, ID
| Mouse Mouse
| +CMI +/−CMI
|-
| colspan="6" | '''Heat shock proteins'''
|-
| height="98" | Calreticulin
| mucin 1 HPV-16 E7
| DC FC, GG
| Mouse Mouse
| +CMI +CMI
|-
| HSP70
| HIV (Gag)
| BC, ID
| Mouse
| +CMI
|-
| colspan="6" | '''Complement inhibitor'''
|-
| IMX313
| HIV (Tat)
| FC, ID
| Mouse
| +Ab, +CMI
|-
| colspan="6" | '''Cytolytic protein'''
|-
| height="188" | PRF
| HIV (Gag) HCV (NS3) HCV (NS345B)
| BC, ID BC, ID BC, ID
| Mouse Mouse, Pig Mouse
| +CMI +CMI +CMI
|}

[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6630607/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6630607/]
[[Category:Vaccine]]

DNA Vaccines - Revision history

Paul.xu: Created page with "Molecular adjuvants and immunogenicity of DNA vaccines in animals. {| border="0" cellspacing="0" |- | '''Adjuvants''' | '''Antigens''' | '''Delivery''' | '''Host''' | '''Resp..."