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== References == <div> #Douek, D. C., et al. Changes in thymic function with age and during the treatment of HIV infection. Nature. 396, (6712), 690-695<br/>(1998). #Zelm, M. C., Szczepanski, T., van der Burg, M., van Dongen, J. J. M. Replication history of B lymphocytes reveals homeostatic proliferation and extensive antigen-induced B cell expansion. J. Exp. Med. 204, (3), 645-655 (2007). #Fronkova, E., et al. B-cell reconstitution after allogeneic SCT impairs minimal residual disease monitoring in children with ALL. Bone<br/>Marrow Transplant. 42, (3), 187-196 (2008). #Sottini, A., et al. Simultaneous quantification of recent thymic T-cell and bone marrow B-cell emigrants in patients with primary immunodeficiency undergone to stem cell transplantation. Clin. Immunol. 136, (2), 217-227 (2010). #Serana, F., et al. Thymic and bone marrow output in patients with common variable immunodeficiency. J. Clin. Immunol. 31, (4), 540-549<br/>(2011). #Zanotti, C., et al. Opposite effects of interferon-β on new B and T cell release from production sites in sclerosis. J. Neuroimmunol.<br/>240-241, 147-150 (2011). #Zanotti, C., et al. Peripheral accumulation of newly produced T and B lymphocytes in natalizumab-treated multiple sclerosis patients.<br/>Clin. Immunol. 145, (1), 19-26 (2012). #Sottini, A., et al. Pre-existing T- and B-cell defects in one progressive multifocal leukoencephalopathy patient. PLoS One. 7, e34493<br/>(2012). #Quiros-Roldan, E., et al. Effects of combined antiretroviral therapy on B- and T-cell release from production sites in long-term treated HIV-1+ patients. J. Transl. Med. 10, 94 (2012). #Mensen, A., et al. Utilization of TREC and KREC quantification for the monitoring of early T- and B-cell neogenesis in adult patients after allogeneic hematopoietic stem cell transplantation. J. Transl. Med. 11, 188 (2013). #Serana, F., et al. The different extent of B and T cell immune reconstitution after hematopoietic stem cell transplantation and enzyme replacement therapies in SCID patients with adenosine deaminase deficiency. J. Immunol. 185, (12), 7713-7722 (2010). #Borte, S., et al. Neonatal screening for severe primary immunodeficiency diseases using high-throughput triplex real-time PCR.<br/>Blood. 119, (11), 2552-2555 (2012). #Baker, M. W., et al. Implementing routine testing for severe combined immunodeficiency within Wisconsin's newborn screening program.<br/>Public Health Rep. 125, (2), 88-95 (2010). #Lorenzi, A. R., et al. Determination of thymic function directly from peripheral blood: a validated modification to an established<br/>method. J. Immunol. Meth. 339, (2), 185-194 (2008). #De Boer, R. J., Perelson, A. S. Quantifying T lymphocyte turnover. J. Theor. Biol. 327, 45-87 (2013). [[File:TREC std curve.jpg|RTENOTITLE]] [[File:TREC Plasmids.jpg|RTENOTITLE]] </div> [[Category:Diagnostics]]
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