Editing Synthesis of TATs-PEG-PEI (section)

== 3. OPSS-PEG-NHS (Orthopyridyl disulfide PDP PEG Succinimidyl ester) ==

[[File:OPSS-PEG-NHS.jpg|RTENOTITLE]]



OPSS-PEG-NHS is a linear heterobifunctional PEG reagent with an OPSS and a NHS ester. It is a useful crosslinking reagent with a PEG spacer. OPSS stands for ortho-pyridyl disulfide or ortho pyridyldithio and reacts with thiol, SH, sulfhydryl or mercapto to form a S-S bond. OPSS is sometimes called PDP, pyridyl dithio propionate. NHS ester is an activated carboxylic acid and can react with '''amine'''.&nbsp; Can be used to Crosslinking Antibody to Nanoparticles

Orthopyridyl disulfide functionalized polyethylene glycol NHS(NHS-PEG-OPSS) is a'''thiol (-SH) and amino reactive PEG derivative''' that can be used to modify protein, peptide or any other surfaces via available thiol (sulfulhydryl) group in cysteine residues to generate a'''cleavable disulfide bond'''. OPSS PEGs react with thiol groups at pH 5.0~6.5.

Heterobifunctional OPSS PEG Succinimidyl Carboxymethyl Ester products from JenKem Technology are generally employed as crosslinking agents or as spacers between two different chemical entities. The PEG moiety in the heterofunctional PEG derivatives provides water solubility, biocompatibility, and flexibility. The'''thiol reactive OPSS group offers the ability to form a disulfide bond''', while '''the SCM group reacts with the amine group of lysine(s)'''. Applications are especially geared towards the development of antibody drug conjugates (ADC’s).



PG2-NSOS-3k OPSS-PEG-NHS, MW 3400 $325

PG2-NSOS-2k OPSS-PEG-NHS, MW 2000 $385

[http://www.nanocs.com/PEG/SPEG.htm http://www.nanocs.com/PEG/SPEG.htm]

[http://www.creativepegworks.com/product_view.php?cid=8&pid=3&sid=36&id=600 http://www.creativepegworks.com/product_view.php?cid=8&pid=3&sid=36&id=600]

[http://www.jenkemusa.com/product/opss-peg-succinimidyl-carboxymethyl-ester http://www.jenkemusa.com/product/opss-peg-succinimidyl-carboxymethyl-ester]
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