Editing Synthesis PolySpermine (section)

=== Stability<br> ===

&nbsp;Mw of PSP-Carb was nearly unchanged when it was incubated in an aqueous buffer of pH 7.4 for 85 days. When incubated at pH 5.8 and 5.0, M w of PSP-Carb dropped to 74.1% and 69.8%, respectively, of its original value in 85 days, suggesting a pH-responsive degradability of the carbamate linkage. PSP-Amide showed higher degradability under the same conditions in that M w of which dropped to 66.3%, 59.6%, and 58.3% of the original M w values over 85 days incubation at pH 7.4, 5.8 and 5.0, respectively (Fig. 2(b)). PSP-Imine degraded remarkably faster than the other two polymers. By incubating at 37 ◦ C and pH 7.4, 5.8 and 5.0 for only 11 h, the Mw of PSP-Imine dropped to 57%, 48% and 42% of its original value, respectively. The rate of degradation of PSP-Carb, PSP-Amide and PSP-Imine accelerated with the dropping of pH.<br>

[[Category:Paul]] [[Category:Transfection]]