Synthesis of CBA

dissolve cystamine dihydrochloride (0.025 mol, 5.3 g) in water (25 ml)
add to a three-necked flask.
Cool the solution 0~5 ◦ C.
Add simultaneously
1. cold acryloyl chloride dichloromethane solution (0.1 mol, 5 mL)
2. cold aqueous NaOH solution (0.2 mol, 10 mL)
Stir the mixture continuously at room temperature for 16 h
Filter the white raw product
Wash 3 times with water.
Crystallize in acetate.
Remove solvent under vaccum