Synthesis HBPAA
Hyperbranched poly(amido amine)s synthesized by Michael addition copolymerization by reacting equal molar ratio of a triamine (DMDPTA) and bisacrylamide monomers (CBA and HMBA).
1. Add CBA (0.260 g, 1.0 mmol) or/and HMBA (0.154 g, 1.0 mmol) to a small vial containing DMDPTA (0.318 g, 2.0 mmol) in methanol/water mixture (3.5 mL, 8/2 v/v).
2. React for 3 days at 50 °C.
3. Add additional 0.1 mmol of DMDPTA to the reaction mixture to consume any residual acrylamide groups, and stir for 12 h at 50 °C.
4. Dialysis against distilled water acidified with HCl to pH 3, then water
5. Recover polymer by freeze drying.
6. Typical yield after dialysis was 30â40%.
N,Nâ²-cystaminebisacrylamide (CBA)
N,Nâ²-hexamethylenebisacrylamide (HMBA)
N,N-dimethyldipropylenetriamine (DMDPTA, Aldrich)
