BioSimilars

Rational protein structure/function technologies

      Glyco-engineering Humanized anti-CD20 monoclonal antibody (Gazyva)

Fc fusion

     VEGFR Fc-fusion (Eylea)
    CTLA-4 Fc-fusion (Nulojix)
    Glucagon-like peptide- 
    1 receptor agonist Fc-fusion (Trulicity)
    VEGFR Fc-fusion (Zaltrap)
    Recombinant factor IX Fc fusion (Alprolix
    Recombinant factor VIII Fc-fusion (Eloctate)
    Albumin fusion 15	GLP-1 receptor agonist-albumin fusion (Tanzeum)
    Recombinant factor IX albumin fusion (Idelvion)

PEGylation

     PEGylated IFNβ-1a (Plegridy)
    Recombinant factor VIII PEGylated (Adynovate)

Antibody-drug conjugates

      Humanized anti-HER2/neu conjugated to emtansine (Kadcyla)

Mouse/human chimeric

      anti-CD30 (Adcetris)

Humanized mAbs

     Anti-human epidermal growth factor receptor 2 (HER2) (Perjeta)
    Anti-HER2/neu conjugated to emtansine (Kadcyla)
    Anti-IL-6 receptor (Actemra)
    Anti-CD20 (obinutuzumab; Gazyva)
    Anti-integrin a4b7 (LPAM-1) (Entyvio)
    Anti-PD-1 (Keytruda)
    Anti-dabigatran (Praxbind)
    Anti-IL-5 (Nucala)
    Anti-CD319 (SLAMF7) (Empliciti)
    Anti-IL-17a (Taltz)
    Anti-IL-5 (Cinqair)
    Anti-PD-L1 (Tecentriq)
    Anti-CD25 (Zinbryta)

Mouse/human chimeric mAbs

     Anti-CD30 (Adcetris)
    Anti-IL-6 (Sylvant)
    Anti-GD2 (Unituxin)
    Anti- Bacillus anthracis (Anthim)
    Anti-TNFα (Inflectra)